Ibuprofen and Acetaminophen are both used for pain relief, but are they the same? And do they treat the same symptoms? Acetaminophen is effective for relieving pain and fever, while Ibuprofen relieves pain, fever, and inflammation. Determining which pain reliever to take is a matter of finding what works best for you. However, here are some general guidelines to help you choose depending on the type of pain you are experiencing.